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The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitreoretinopathy: the Retina 4 Project.

Ophthalmology 2013, vol. 120, issue 3

PURPOSE

To compare the distribution of a p53 gene polymorphism among European subjects undergoing primary retinal detachment (RD) surgery in relation to the development of proliferative vitreoretinopathy (PVR).

DESIGN

Case-controlled gene association study conducted as a component of the Retina 4 Project (a European multicenter study).

PARTICIPANTS AND CONTROLS

Five hundred fifty DNA samples, 134 with PVR secondary to primary RD and 416 with RD without PVR.

METHODS

The p53 codon 72 polymorphism (rs1042522) was analyzed using allele-specific primer polymerase chain reaction. Proportions of genotypes and the proline (Pro-P) homozygote groups between subsamples from different countries were analyzed in 2 phases. In the first, subsamples from Spain and Portugal were analyzed. After significant results were found, samples from the United Kingdom (UK) and The Netherlands were analyzed (second phase). Genotypic and allelic frequencies were compared between cases and controls in the global sample.

MAIN OUTCOME MEASURES

Single significant associations with PVR.

RESULTS

A significant difference (P

CONCLUSIONS

Results indicate that the Pro variant of p53 codon 72 polymorphism is associated with a higher risk of PVR developing after a primary RD. Further studies are necessary to understand the role of this polymorphism in the development of PVR.

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