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Accuracy Assessment of Intra and Inter-Visit Fundus Image Registration for Diabetic Retinopathy Screening.

Invest. Ophthalmol. Vis. Sci. 2015, vol. 56, issue 3

Purpose: To evaluate the accuracy of a recently developed fundus image registration method (Weighted Vasculature Registration or WEVAR) and to compare it with two top-ranked state-of-the-art commercial fundus mosaicking programs (i2k Retina, DualAlign LLC and Merge Eye Care PACS, formerly named OIS AutoMontage) in the context of diabetic retinopathy (DR) screening. Methods: Fundus images of 70 diabetic patients who visited the Rotterdam Eye Hospital in and for a diabetic retinopathy screening program were registered by all three programs. The registration results were used to produce mosaics from fundus photos that were normalized for luminance and contrast to improve the visibility of small details. These mosaics were subsequently evaluated and ranked by two expert graders to assess the registration accuracy. Results: Merge Eye Care PACS had high registration failure rates compared to both WEVAR and i2k Retina (p = 8 x 10-6 and p = 0.002, respectively). WEVAR showed significantly higher registration accuracy than i2k Retina in both intra-visit (pLink to full publication

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