2014-28: Clinical, experimental, and genetic studies on the etiology of central serous chorioretinopathy
Central serous chorioretinopathy (CSC) is a specific and relatively common form of macular degeneration. This eye disease, which can present as an acute or a chronic disease, can cause a marked loss of central vision due to fluid leakage under the neuroretina, leading to irreversible damage of the photoreceptors when left untreated. At present, our knowledge on the pathogenesis of CSC is very scarce. Despite convincing evidence of a genetic predisposition for CSC, no studies have been published thus far on the genetic causes of CSC. Both the use of corticosteroids and stress are strongly associated with the disease, but the underlying pathogenetic mechanism(s) remain to be elucidated. An association between CSC and endogenous hypercortisolism has also been described.The key objectives of this study are to identify both the genetic background and pathophysiological mechanisms that underlie CSC.