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2007-01: The retro-orbital fibrobast: a key player in Graves’ ophthalmopathy and a target for therapy.

Orbit and melanoma
Molecular biology
Investigator Initiated Research
Inclusion open since 1-10-2007

In the present model of immune pathogenesis of Graves’ ophtalmopathy, a concerted action of various immune cells and antibodies is conjectured to cause this thyroid eye disease. In vitro studies may help to understand these processes more thoroughly. The objective of this study is the Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory. Materials for this model will be derived from:

* Graves’ ophthalmopathy patients.

* Otherwise healthy control patients scheduled for ophthalmoplastic or reconstructive surgery.

* Newly diagnosed hyperthyroid Graves’ patients (no ophthalmological symptoms).

* Newly diagnosed patients with hypothyroidism due to Hashimoto’s autoimmune thyroiditis.

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