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2007-03: Quantitative monitoring of the inflammatory process in active HSV keratitis by in vivo confocal microscopy, a pilot study

Cornea and infections
Medical devices and techniques
Investigator Initiated Research
Inclusion open since 8-2-2008

Confocal microscopy is a non-invasive, real-time, in vivo imaging technique which has been put forward as a potential clinical tool for inspection of the cornea. Presently, active Herpes Simplex Virus-1 (HSV) keratitis is evaluated by slit lamp inspection. For an objective follow up of the inflammatory process, however, this method does not meet the standards of sufficient accuracy and reproducibility. In this study, it will be investigated whether the improved image quality of the most recent version of the confocal microscope can provide a reliable quantitative parameter for a more adequate follow up of the inflammatory process of active HSV keratitis. This is a prospective cohort study in which all patients presenting with active HSV keratitis will be asked to participate. The main study endpoint is the stromal reflectivity (Z-scan) of the HSV-infected eye.

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