2010-01: Thrombin and factor Xa driven pro-fibrotic and inflammatory behavior of RPE cells provide a rationale for a randomized clinical trial of preventive therapy for PVR
Proliferative vitreoretinopathy (PVR) is an inflammatory scarring (fibrotic) process in which retinal pigment epithelial (RPE) cells play an important role. PVR is the major cause of recurrent retinal detachment (RD) and an unfavourable functional outcome after retinal detachment surgery, for which no satisfying prevention is present at this moment. A better understanding of the pathophysiological processes involved in PVR would help to identify novel prevention options. The aim of this project is to examine the role of the coagulation proteins thrombin and factor Xa (FXa) in the pathophysiology of PVR in order to generate a solid foundation to undertake a randomized clinical trial for a drug target to modify RPE proliferation and migration and prevent the development of PVR in patients with rhegmatogenous retinal detachment.