2003-01: Examination of the immunomodulatory role of corneal epithelial cells and fibroblasts in the immunopathogenesis of herpetic stromal keratitis.
Cornea and infections
Investigator Initiated Research
Inclusion open since 1-6-2003
Herpetic stromal keratitis (HSK) is a chronic herpes simplex virus (HSV)-induced corneal inflammation that can lead to blindness. Intra-corneal inflammatory reactions in HSK are the result of a complex interaction (via inflammatory mediators) between HSV, corneal infiltrating inflammatory cells and corneal "own" cells: corneal fibroblasts, and epithelial cells. The role of the corneal cells as immunomodulatory cell type will be studied. Immunopathogenesis of HSK The goal of the project is to investigate the immunomodulatory role of corneal epithelial cells, and fibroblasts within the immunopathogenesis of HSK in vitro and in vivo.