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2005-07: Intra-tumor heterogeneity in uveal melanoma.

Orbit and melanoma
Molecular biology
Investigator Initiated Research
Inclusion open since 1-6-2005

Genetic research has shown that tumor specific chromosomal abnormalities in uveal melanoma strongly associated with metastasis. This duplication of a part of chromosome 1 associates with a poor prognosis is a new finding. Melanomas with amplification on chromosome 1 was a small group of heterogeneous tumors. In these tumors, aneuploid multiple clones are present (with 3 or 4 copies of multiple chromosomes). This raises new questions: Is there heterogeneity in multiple melanoma? Can this be overlooked because we only use a small piece of tissue? Is aneuploidy the result of an advanced tumor that initially had tumor-specific deviations? The aim of this study is to map heterogeneity in uveal melanomas on histological and genetic level and relate it to the prognosis of individual patients. Iris melanomas are less common intraocular tumors with a better prognosis than uveal melanomas. We will investigate these melanomas and compare the results with uveal melanomas.

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