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2012-15: Evaluation of intra- and transretinal blood flow in Retinal Angiomatous Proliferation detected with phase-resolved Optical Coherence Tomography before and after treatment

Medical retina
Investigator Initiated Research
Inclusion open since 1-12-2012

Retinal angiomatous proliferation (RAP) is a distinct form of neovascular age-related macular degeneration (ARMD) that responds poorly to anti-VEGF monotherapy. It is difficult to demonstrate RAP with conventional imaging (fluorescein or indocyanine angiography). Recently, the Imaging group at R.O.I. was able to demonstrate abnormal flow corresponding to intraretinal neovascularisation in treatment-naïve RAP patients with high resolution Doppler Optical Coherence Tomography (OCT) imaging. This study aims to visualize the different components of RAP lesions with high resolution Doppler OCT, and to evaluate the change in intra- and transretinal flow after treatment. The study population comprises treatment-naïve patients who present with newly developed RAP as part of exudative ARMD in one eye. The primary endpoint of this study is structural changes and intra-/transretinal blood flow.

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