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2013-26: The effect of Optic Neuritis, NAION and Pituitary Tumors on the Attenuation Coefficient of the Retinal Nerve Fiber Layer derived from Spectral Domain Optical Coherence Tomography images

Neuro-ophthalmology
Medical devices and techniques
Investigator Initiated Research
Inclusion open since 1-5-2014

Spectral Domain – Optical Coherence Tomography (SD-OCT) provides images of structures such as the retinal nerve fiber layer (RNFL). However, conventional SD-OCT diagnostics of glaucoma, a condition affecting the RNFL, is relatively susceptible to artefacts. Therefore, another approach, less prone to artefacts, was developed, i.e. by means of the attenuation coefficient (AC). The AC is a quantitative, objective measure for the scattering and absorption properties of tissue. Recently, we have shown that the AC of the RNFL decreases with the severity of glaucoma. It is expected that the AC may also serve for better detection of RNFL damage caused by various other diseases. The objective of this prospective, observational study is to study AC changes of the RNFL in neuro-ophthalmic diseases in a Study population of 10 optic neuritis (ON) patients, 10 pituitary tumor patients, 10 nonarteritic anterior ischemic optic neuropathy (NAION) patients.

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