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2009-35: Monitoring the inflammatory process in active herpetic keratitis by in vivo confocal icroscopy: clinical relevance.

Cornea and infections
Medical devices and techniques
Investigator Initiated Research
Inclusion open since 1-9-2011

Rationale: Confocal microscopy is a non-invasive, real-time, in vivo imaging technique which has been put forward as an additional clinical tool for inspection of the cornea. Presently disease activity of herpetic keratitis is evaluated by slit lamp inspection. For an objective follow up of the inflammatory process, this method does not meet the standards of sufficient accuracy and reproducibility. A large study on endothelial involvement in herpetic keratitis showed that In Vivo Confocal Microscopy (IVCM) has an additional role in detecting active endotheliitis which remains undetected in slit lamp examination. In a pilot study we investigated the role of confocal microscopy as reliable quantitative parameter for a more adequate follow up of the inflammatory process of active herpetic keratitis. The objective of this Prospective randomised study is to test the hypothesis that IVCM is a clinical relevant tool to monitor the inflammatory process due to herpetic keratitis.

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